Well, issue #1 is $250 raw and issue #8, which still has a super low print run is $25. Speculators see those numbers and go directly to dcb or midtown and place an order for 50 copies of whatever issue is currently up for Previews ordering. Preorders are going to explode for issue #10 based on spec buying.
East of West is going to have a 30K+ print run only because of the aftermarket sucess of Saga, Nowhere Men and Manhattan Projects, among others. All of the jackazzes (myself included) are preordering the hell out of it, hoping for another $20 plus back issue.
The increase in ordering is directly tied to the secondary market.