The Marvel Cinematic Universe's most popular streaming movie on Disney+ in 2022 is surprisingly Eternals - the franchise's lowest-rated movie.
https://screenrant.com/eternals-most-streamed-mcu-disney-plus-movie-2022/
"...Despite being the most forgettable MCU movie, Eternals has proved its staying power on the Disney+ streaming platform. According to Nielsen, Eternals was the ninth most popular Disney+ movie in 2022 with 4.236 billion viewing hours – the only MCU movie to crack Disney's top 10. Eternals was also listed as the 13th most popular streaming movie in general, making it an absolute standout for the platform, despite its meager reception at the box office. It earned a mere $402.1 million — low for an MCU movie — on a $200 million budget..."