I started with the assumption that the OP meant a book with great story and art that didn't include anything that could be easily monetised in the current market, such as no first appearance of a minor character, but, as a theoretical exercise, should still have much more respect, and a much higher price, because of its intrinsic high level of quality.
So, say, a bargain bin, cheap item with great story and artwork, such as Batman / Grendel rather than say, most of EC's New Trend line, with great quality but which are expensive items.