I know others have said this before, but in my personal quest to original Watterson stuff, and finding out how much it goes for, I was struck by the fact this is exactly why the man didn't commercialize anything or sell originals.
To be honest, I don't agree with his worldview, but over time and learning about how he feels about his art, I've decided out of respect (even if I get a crazy opportunity to grab something for a steal) to never buy any originals until after he dies.
That said, he seems to feel so strongly about this stuff, it wouldn't surprise me if everything winds up in a museum or burned.