aw man, i hope not. cannot stand anime. why would it have to be on Cartoon Network? i guess id be ok with an animated series, but, id prefer live action. if it was a series of films, say a trilogy, the budget would be a lot more, especially if you got another production company to help out Skybound. Dreamworks and Universal have that kind of money and as far as i know, aren't tied into the Marvel/DC universes.
Cartoon Network is the best outlet for Cartoons in general. Anything that airs on Cartoon Network Ends up on Netflix. Madhouse did a great job on the X-MEN anime. it was a story but it was well animated! If it turns into an anime it would be streamed on multiple sites. This in turn gives a chance for those that ignored it during it's initial broadcast, just like Breaking Bad.
Smallville is a prime example how an iconic character cannot seem get a budget to put on a proper show. Would you really like 10 years of Invincible on a budget and cheesy -script?
A film would simply not work. Only Lionsgate would take a risk on an Indy Comic and wouldn't shell out more than 50 Million on it. I think they would have to have Mark on foot in the first movie. Do you really think an R Rated Invincible could do well on the big screen?