Oh definitely. All the indies are rapidly rising (have you seen Albedo 2?) , and Cerebus 1 is the original Indie bad boy that started it all.
Collectors want it because its the first independent series (not DC or Marvel) that went mainstream and propelled the next generation of indie comic creators including Teenage Mutant Ninja Turtles, Bone, Usagi and even Image comics. Todd McFarlane was obviously a fan.
Now on top of that historical aspect, there is the 2000 print run and the strange history of counterfeits showing up in 1982. There was no question this book would shoot back up eventually. It will always hold a place in comic book history ..