Thanks for the shout-out! (I'm like Beetlejuice; if you mention my URL three times in a row I suddenly appear
Honestly, this exact question is what lead me to even start compiling said guide to begin with (although at the time UXM was only up to about #419).
Generally, the path of least resistance is going to be:
- Epics/MMW for #1-66
- Omnis for #94-175
- Upcoming MMW for #176-188
- Epics & pre-Epic trade from #189-209
- OHCs (or trade equivalents, which are cheaper) for #210-243, with a gap before Fall of the Mutants
- The Claremont/Lee Omnis + X-Tinction Agenda for #244-280
- Bishop's Crossing + X-Cutioner's Song + Fatal Attractions for #280-305
- Things are a bit messy until #320
- Road to Onslaught trades for #322-332
- Onslaught trades or Omni for #333-337
- Several gaps and older collections from #338-387
- Various trades from #388-409
- Initial-release trades available from #410-545 with no gaps
To all: please just holler here, on my page, or via Twitter if anyone has questions about reading this run (or, frankly, any Marvel comics run) via collected editions. I can help steer you the right way.