I got my fridge at a local shop after the cluelessness of the folks at Home Depot sent my wife into a rage. Slightly cheaper, next day delivery (because their warehouse is in Brooklyn, not 8 million miles away), and delivery guys who know how to get the appliances into old houses without destroying them. Home depot told us one model could not get through our door because they could not take the fridge door off. The local place was "of course you can take the door off." Admittedly, the local place is not exactly a "mom and pop shop," but it is one single location. Of course, my wife likes it when the sales people know the product, rather than someone working minimum wage who is stuck in appliances that day who might be in the paint section the next. OTOH, when I just wanted a cheap dryer I went big box. And then they installed it defectively and I had a gas leak that was slowly poisoning us.
As for comics...I can usually find something worthwhile in most shops. Admittedly, it might not be worth the time hunting, but it's fun. Of course, I have pretty broad collecting goals. Lots of folks here are down on shops in general. But let's face it, if all those shops disappear, the hobby probably has another 5 years left. As for cons, I always find tons of good stuff to buy, but yes, you're rarely going to get a real deal on a three or four digit key.