I think it's inevitable that the comic art market will start to resemble the broader contemporary art market - original work as the most desirable, commanding the highest prices, then the monoprint, then the first broad print run (with printer or artist proofs attracting a premium), then the second run, etc.
Actual original artwork will always be the pinnacle, and there will always be people for whom that's the only thing worth collecting, but for people coming into the hobby now, some highly desirable pieces are only available are prints because they were fully digital - and given that we see nostalgia as a significant driver for values in original art, it would be reasonable to assume that the same will happen for well-known pieces that are fully digital.
I've bought a few digital pieces that I'm very happy with, at good prices (although I'm still annoyed with myself that I didn't pick up the Thor 705 cover that Dauterman was selling when it was available) but I looked at the Jimenez Punchline cover and balked at the price tag - but I do think it's entirely possible that I could be regretting that decision in a few decades. It feels like it's a market in its infancy, and there's still a lot of price discovery going on, so I guess we'll see if it continues to evolve, or if it hits a plateau. But given the broad trend for artists to work digitally - which does look like it's slowing down - I find that hard to imagine.