For me, having only recently gotten into collecting graded comics, so far it is 9.8 Spawn #9, written by Neil Gaiman & signed by Todd McFarlane:
Reasons:
Spawn toys were my favorite things to collect growing up (Spawn comics not so much)
My sister's name is Angela! (she makes first appearance)
Todd McFarlane is one of my idols, but only for his creative prowess as he was quite vicious as a businessman, going against his original creed for starting Image (preserving creator-owned rights) by battling Neil Gaiman for the rights to Angela in courts for over a decade (Neil prevailed then swiftly sold the rights to Marvel)
Jim Lee is one of my idols and drew a poster in the book
Which CGC comic is your pride and joy and why?