This quote reinforces the likelihood of an "alternate universe" story line.
-J.
Ya, some nice alternate universe background, before she joins secret wars BATTLEWORLD with every other character.
I'm definitely interested to see how they do this since the character is premised on a "what if" concept that seems to like to play off different incarnations/re-imaginings of other existing characters as well. I'm almost thinking it would be more interesting leaving her in her own "alternate universe" where all of those different takes on other characters can actually happen, rather than her being one of three other featured "spider-women" in the same continuity.
-J.
She was never a "what if" character, she exists in another universe which was what the in continuity spider verse was all about. She was always meant to interact with the 616 universe.