I like this post. Good stuff. I guess, like anything else, "significant" is subjective. From the perspective of the cosmic universe, yes, FF#48 is certainly a more significant key and has opened up a much larger universe than what the Black Panther will open up with Wakanda....on the pages and on the silver screen. If you're looking at "significant" from a character recognition perspective, and from a market value perspective, FF#52 will or has already outpaced FF#48. If Marvel ever gets the rights back that will surely change but for now, from that angle, FF#52 wins in my book.