Retired due to his health issues.
From Wiki - Pérez is married to Carol Flynn. He has no children. He has a brother, David, and a niece and nephew.He is diabetic, and has undergone surgery for diabetic retinopathy. In May 2017, Pérez was admitted to a hospital with chest pains and was diagnosed as having had a heart attack while travelling to New Jersey for a convention. He was subsequently released from the hospital after having a coronary stent fitted.
His letters to his loyal fans: https://www.comicsbeat.com/george-perez-retirement/