I think if the logistics were started sooner, you could get a really cool 1-4 volume put together. The original arc is 4 issues correct? NYCC is a little too far away. Those who would want to read the series will have had a tpb vol 1 for at least a month or more. Not sure a NYCC volume would help boost sales.. it would just be a collectible. The idea would be to get something special in someone's hands, asap, and get them to their LCS to add it to their sub (or sub for the first time.)
SDCC still has a diverse crowd and if promoted properly, this sort of book would thrive in those conditions.
Todd The Ugliest Kidd on Earth Vol 1: The SDCC Ugliest Hardcover Edition