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Omega the Unknown is a humanoid being of superhuman power bio-engineered by an extraterrestrial mechanoid race named the Protar, from the planet Protaris in the Regreb System in the Milky Way Galaxy. The Protar, foreseeing its own extinction, decided to create an ideal race of true humanoids as their legacy to the cosmos. Their penultimate model, later called Omega, was placed on the planet Srenesk (an anagram of series co-writer [Mary] "Skrenes") to learn. He commandeered a Protar starship and fled to Earth after inadvertently destroying the world on which he was placed. The Earth was the home of the final "model" in his series, the artificially created boy James-Michael Starling, whom Omega sought to protect from the Protar.[11]
While on Earth, Omega was employed for odd jobs by a New York City pawn-broker, and had a number of battles with local beings. He battled the Hulk,[10]Electro,[12]Blockbuster,[13] and Nitro.[14] While later embroiled in a rematch with Blockbuster, the second Foolkiller saved Omega's life by murdering Blockbuster.[15]
Omega was finally shot dead in Las Vegas by the Las Vegas Police while battling Ruby Thursday; the police thought Omega was assaulting Ruby.[16] James-Michael Starling, who had inherited Omega's power, learned the true origin of himself and Omega but refused to accept the truth. He threatened to use the power of Earth's biosphere against the Defenders. Seeing the error of his decision, he ended his own life when he turned the power inward and self-destructed.[5]
In 2010, Comics Bulletin ranked Gerber and Mooney's run on Omega the Unknown tenth on its list of the "Top 10 1970s Marvels".[17]
Comic Book Resources placed Omega the Unknown as one of "15 Superheroes Marvel Wants You To Forget", stating "his complicated history makes it exceedingly unlikely that he'll return to the Marvel universe."[18]