It really depends on the collector. Speaking for myself only, my collection has moved from being mainly blue labels to a yellow label majority. I also personally know some collectors who abhor anything that defaces a cover such as an autograph, but make that same Signature Series book available for sale with the autograph on the first page and they'll try to buy it. Of course, always assuming they were interested in that particular issue to begin with.
Be sure to cast your votes here: SIGNATURES:INTERIOR VS. EXTERIOR