What grade for Hulk 180s and what time frame? If you bought CGC 9.4s ($2400) at the start of this year you are down $300-$400 per copy. Buying Hulk 181 CGC 9.4 at the same time would have you with a $600-$800 profit. Doing the math, 4 x CGC 9.4 180s at a loss of $300 per copy based on current prices = $1200 net loss, while buying one CGC 9.4 copy of Hulk #181 for the same amount would have generated a small profit under this scenario.
If we go back to Jan 2018, then Hulk #181 CGC 9.4 was a $5300-$5400 book (and I am still kicking myself at passing on two W page copies at that price in March 2018). So let's say you buy 2 copies for $10,500. At the same time, Hulk #180 CGC 9.4 was a ~$1000 book (some sales higher, some lower) so you could buy 10 copies for $10,500. At the current prices, you would net ~$1100 per copy of CGC 9.4 of Hulk #180 = $11,000 profit, while the Hulk #181 would have netted around $5,200 per copy based on current prices for a net total of $10,400. In this case, the Hulk #180 CGC 9.4 barely wins out.
Going forward, unless the market suddenly shifts to Hulk #180 as the first appearance of Wolverine, then you are likely better off with Hulk #181 IMHO as #180 will only run up when #181 jumps further.