I think so many people and speculators missed many boats since the craze began, and are trying to get a head start on anything remotely key-ish, though I think Annihilus is a strong candidate to speculate on. For [possible] example; Thor #160. I haven't looked into it, but I hear it's hot. Is it the first meeting of Thor and Galactus? I don't recall one prior to this, but even if it is, so what? Unless the MCU meeting shakes the hobby like nothing else in recent times, so what?
I just recently bothered to find out what FOMO means. In this current society I can see this being a real problem. Not real as in 'true', more like as in .