I think the show could be a good way to introduce mysticism and magic into the universe in a way they haven't yet, sort of like what Arrow is doing right now. It'd be great to have a hero who wasn't either manufactured or extra-terrestrial, because as of right now, I'm not really sure I can think of anyone in the MCU that doesn't have:
A: Powers that are from a suit
B: Powers because they aren't human
C: Powers given to them by science
I might be wrong though, but even with the twins in Age of Ultron, they gave them powers from experimentation.