Absolutely!
The pre-here genre was a breeding and testing ground for a lot of ideas that Stan and the others ended up fleshing out later in Marvel's super-hero period.
Tales of Suspense 6 has a great story about "mutants" -- defined in that story as people who have mutated to develop extra powers beyond the scope of normal humans -- and is clearly the prototypical theory for the entire X-Men and mutant mythos of the Marvel Universe!!!! And the main characater who poo-poo's the idea ends being a person with the power to phase through soild objects (hello Kitty Pryde prototype??)
I also loved how many of these monsters were resurrected in the Bronze Age and beyond (Hulk fought the Glob, Zzutak, and others; Xemnu (the Hulk protoype) was a Defenders villain; Fin Fang Foom and Colossus were used in Astonishing Tales; and FFF returned again in Iron Man in the late 200s).
PS: Angelo, that's a nice pickup from Ebay!
I really hope Marvel decides to reprint the rest of the pre-hero titles in the Masterwork series. I'd love to read all those prototype stories....and look at the great art, of course.
Angelo