bold part - absolutely not possible, not even slightly.
as for "other comic book movies", marvel is in its own separate world. There are comic book movies, and Marvel movies, and their fates and futures, long ago separated...
Ant-man is Marvel's first heist film, and just one of their many moves into all genres. Nuff said
While Ant-Man doesn't look awesome to me, if it plays an important role in the entire MU then it should do well as people will need to see it to stay in the loop.
I don't know about that. Despite my best intentions I've never seen either of the Thor movies or watched an episode of Shield or Agent Carter, and I followed Avengers 2 just fine (at least I thought I did). I think Marvel would shoot themselves in the foot if you were forced to see everything for a later film to make sense. At that point it is easier to just see nothing than it is to watch everything.
I should have put 'need' in quotations.
Every movie can stand alone but there is a large amount of crossover that compels people to see what is going on that is new.
For example, I'd never watch the Ghost Rider / Nic Cage movies but I will watch Ant-Man because of it's role in MU.