Some books that I think will be hot or hotter in 2016 are:
1- Southern Bastards. Tons of room for growth as the television show progresses. The story is interesting, and done well. Pretty low print run on some issues. I can see this book quadrupling in price. Right now you can probably find it for $10 or under.
2- Hyperion. Lots of the squadron supreme stories can be found for a good price. From the toys and cartoons that Marvel is releasing, it's pretty obvious that they are trying to increase the popularity of Hyperion.
3- Citizen V/Thunderbolts. There was a little bit of talk about Red Hulk/Thunderbolts this year, and i think a Thunderbolts movie or tv show could be received well, and would work well with Agents of Shield.
4- Wes Craven related books. Both The Disciples and Coming of Rage came out this year, but Wes Craven also passed, but his company is still going, and either of these stories could be made for other medias. The Disciples had a press release before the book was even out about being developed by Craven's company. Also Steve Niles worked on these books, and they are really great reads.
5- White Fox, Guillotine, Gwenpool, Silk, Spider-Gwen, Singularity, America Chavez, Synapse (basically any of the Inhumans), and Shredded Man.