I'm voting no but just because Man Thing has really no chance of creating a stir in movies or in modern comics (reboot). I'd say a book like Adventures Into Fear 19 or Vampirella 1 would be a safer bets since Howard the Duck could see a reboot or a show and Vampirella is always in the mix for a tv show or movie.
You know, in an age where marginal characters like Groot and Rocket Raccoon and WTF? characters like Squirrel Girl can become hot commodities, anything is possible. To declare otherwise is ignoring what has happened in the recent past. Does that mean that Man Thing will become hot? (a hot Man Thing??? ) I have no idea but I surely can't rule it out, given the wackiness we've seen. Remember, books like She-hulk 1 and Ms Marvel 1 and Black Panther 1 and Eternals 1 and Nova 1 were considered garbage books for years. Now look where they are.