I see a fair amount of blood and vampire stabbing on regular TV, I'm not sure why it NEEDs to be R. Supernatural has gotten fairly gruesome. I was watching SHIELD last night and my wife couldn't believe some scene was on regular TV.
Anyway, i saw this: https://screenrant.com/deadpool-blade-mcu-phase-5-connection-why/
Other than Ryan Reynolds being in one of the Blade movies, I don't see why there would be ANY connection between Deadpool and Blade.
BUT I can easily see a plotline where Blade has been doing his thing for years and Fury (or Rambeau or whoever was running things) recruiting him for SHIELD / SWORD to handle the vampire problem. Because we would have developed a vampire problem during the "blip" because, maybe in theory, vampires are not "life" and did not get wiped out. So just as many vampires, half as many people, for 5 years, society falling apart. Frankly, a Ronin / Blade team up would have made sense during that period, but Blade can stand on is own on the MCU periphery. This was a franchise that has THREE movies. Two of which made money. It is a little condescending to think a humor character like Deadpool needs to bring him into the MCU.