Most of my collection (any age) is between F and VF in grade.
I tend to pick NM copies only of books I particularly love or consider more meaningful for the story.
The little GA I have is mostly low grade, with some getting close to F, but this is just because of the rarity and the prices.
In general, whatever grade I buy, for me the book has to hold together: I would favor a low to mid grade book, if it presents well, over a high grade book with a significant flaw like a popped staple.
I also don’t care if there are issues going on with the back cover, as long as it is an advertisement picture. I have a Fantastic Four which would be easily a stunning NM but has water damage on the back cover.