Thats a lot of speculation on your part, and I can't make a connection between random 1st appearance books being sold at inflated prices and comic book shops going out of business, as comic book shops are staying in business selling new releases as the majority of their income, but again, I am okay with all of that.
If you havent spent the last 2-3 years (or 8-10 years) chasing down the good stuff to stash away, at this point, I wouldnt start. And if anyone wants to start, I'll be the first to sell those books to them.