If you're suggesting a "perfect storm," that suggest to me you want all of these things together. But you're unlikely to get #5 if #2 is already the case. Your best bet is recognizing that the team has talent which the collecting community hasn't fully recognized yet.
Given the criteria, Outcast by Kirkman and Azaceta is one recent book that comes closest to filling the criteria.
Agreed. I think you're just looking to hit on as many of these traits as possible.
Outcast is a good one and Enormous also comes to mind.
My updated list:
1. New Story/Character(s) Introduced (No reboots or established characters getting own series)
2. Highly Regarded Writer/Creative Team
3. Upcoming TV Show/Movie Buzz
4. Ongoing Title (Not limited)
5. Zero or very few variants
6. Low Print Run
7. Great Cover
1. Agreed, though I would venture a guess that something old and familiar will be a big winner in the New All New Very New Marvel U
2. It doesn't matter who writes or draws the story. It only matters that it is way above average or better to me.
3. This seems to matter more with Bronze and Copper Marvel and DC books. Especially on 2nd and 3rd tier characters.
4. The Dark Knight Returns, Watchmen, 30 Days of Night, Last of Us, Kingdom Come, and many more kind of make this up for debate imo.
5. I think Saga's popularity was increased because of the RRP variant #1. I do agree that more than 3 or 4 hurt more than help. Enormous probably wouldn't be as well known without the variants.
6. I think there simply needs to be more demand than supply. There were more than 170,000 1st print Batman #1 books and more than 35,000 copies of Saga.
7. Along with the cover, the story and interior art.
I would add
8. Internet word of mouth/big dealer hype. This causes everybody to take a look at a book. After they read it, then the collectors decide it's value.
9. Perception. It really doesn't matter if a book is really hard to find or not. If you check ebay, the hottest books out are available 24/7. Even Bronze books are very common in great condition but the thought that they might not be is what pushes the market.
I'd also add collecting can defy all the above listed. Its like why are some WD #1 reprints going for hundreds of dollars while othesr are not ( yes some is due to low print run, cover art, etc) but sometimes the intangible plays into why something is desired. It is wanted just because.