All we need are gateway hobbies, something to get the little buggers today to start collecting.
Once they're bitten with the bug of collecting, of organizing their stuff, and learning about the history within, and sharing the experience with others, then we'll have new generations of collectors. I think going forward it's going to be smaller and smaller, but not non-existent. My reasoning is that there are fewer gateway hobbies - not coins, not stamps, fewer into sports cards, and yes fewer into comics. Of course the growth in kids reliving their Pokémon days or reconnecting with their youth through fidget spinners in twenty years might offset that, but I doubt it.
And with each new generation, there will be some percentage of them, however small, that branch out. For instance, I didn't grow up with the Yellow Kid or Tom Mix, nor Captain Tim
Healy or Clyde Beatty for that matter, and I definitely missed all those 50's PCH and Atlas books the first go-around, but that doesn't dampen by appreciation (and lust!) for them now.
So, yes, there is still a little hope.