The Woodridge location most assuredly had potential considering Hollywood Boulevard was practically next door. Mom and/or dad has a few during a showing of the latest superhero movie to hit big screen, then they walk out at the end and the kids say "Oh look, a comic shop! Let's go!" Heck, there's probably plenty of unaccompanied adults that would have had some 16 ounce sized spending inspiration. Execution on the concept must have been poor (I never bothered to visit that location, so I'm just speculating).
Did someone say Woodridge? I used to live 5 minutes from that store; the location (to me) seemed great. There is a Graham Crackers in Naperville and Downers Grove (probably 15-20 mins west/north from Chimera's in Woodridge), but as far as I know there aren't many comic stores further south, out by Lemont, Bolingbrook, etc. That's where they could have potentially pulled in new returning customers; as said before thrift buyers from the movie theater next door should have been good, too. The back issue stock was very sparse and completely random. They had the space to add more but instead did some odd gaming thing.
As to One Stop, I went there once and was amazed by the amount of comics. Probably a lot of great overlooked items in there, but when I went (this was a few years ago), if you wanted to look at back issues you had to specifically ask for it. No digging to be had.
Finally, when did the 2nd and Charles in Aurora close? Was going to head over there tomorrow and it is no longer.